Tenecteplase infusion: The saviour in partially successful thrombolysis of prosthetic heart valve thrombosis

Tenecteplase infusion: The saviour in partially successful thrombolysis of prosthetic heart valve thrombosis

Blog Article

A 20-year-old female, with history of mitral valve replacement presented with recent onset breathlessness.Cine fluoroscopy showed hp pavilion 15-eg1053cl restricted leaflet mobility.Since she was in pulmonary oedema and there was no cardiothoracic surgery backup, she was immediately thrombolysed with tenecteplase 60 mg (1 mg/Kg) intra venous bolus.However, repeat cine revealed partially stuck leaflet turbo air m3f24-1 and transesophageal echocardiography (TEE) showed thrombus measuring 0.35 cm2.

Since symptoms persisted, we administered 0.25 mg/kg IV tenecteplase given over 6 hours.Slow thrombolysis with tenecteplase might be a safe and effective therapeutic strategy in patients with failed initial bolus thrombolytic therapy, especially in resource limited settings.